Synthesis of Multisubstituted Dihydroquinoxaline Derivatives by Tandem  N ‐Alkylation and Addition Reactions of 3‐Oxoquinoxaline‐2‐carboxylates | Zendy

Miyamaru Satoru | Zendy; Umezu Kazuto | Zendy; Ito Akinori | Zendy; Shimizu Makoto | Zendy

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Synthesis of Multisubstituted Dihydroquinoxaline Derivatives by Tandem N ‐Alkylation and Addition Reactions of 3‐Oxoquinoxaline‐2‐carboxylates

Author(s) -

Miyamaru Satoru,

Umezu Kazuto,

Ito Akinori,

Shimizu Makoto

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500225

Subject(s) - chemistry , umpolung , alkylation , ring closing metathesis , tandem , metathesis , tricyclic , organic chemistry , combinatorial chemistry , stereochemistry , catalysis , polymer , materials science , composite material , nucleophile , polymerization

This report describes a one‐pot synthesis of multisubstituted dihydroquinoxalin‐2‐ones using an umpolung N ‐alkylation followed by oxidation and C ‐alkylation reactions. Moreover, the synthesis of tricyclic compounds containing a dihydroquinoxaline skeleton was carried out by ring closing metathesis (RCM) of the resulting N , C ‐bis‐addition products containing olefins.

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