A Simple and Cost‐Effective Method for the Regioselective Deuteration of Phenols | Zendy

Zhan Miao | Zendy; Xu Ruixue | Zendy; Tian Ye | Zendy; Jiang Hongxia | Zendy; Zhao Lifeng | Zendy; Xie Yongmei | Zendy; Chen Yuanwei | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Simple and Cost‐Effective Method for the Regioselective Deuteration of Phenols

Author(s) -

Zhan Miao,

Xu Ruixue,

Tian Ye,

Jiang Hongxia,

Zhao Lifeng,

Xie Yongmei,

Chen Yuanwei

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500192

Subject(s) - regioselectivity , chemistry , phenols , deuterium , catalysis , oxygen atom , functional group , combinatorial chemistry , organic chemistry , computational chemistry , molecule , physics , polymer , quantum mechanics

A highly effective and operationally simple method for the deuteration of phenols using NaOH as a catalyst and D 2 O as the deuterium source is presented. A high regioselectivity for the ortho and/or para hydrogens relative to the oxygen atom was achieved, as well as a high degree of deuterium incorporation. The method also has a high functional‐group tolerance, and allowed the deuteration of complex pharmaceutically interesting substrates.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research