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Iron‐Catalyzed α‐Methylenation of Ketones with N , N ‐Dimethylacetamide: An Approach for α,β‐Unsaturated Carbonyl Compounds
Author(s) -
Li YiMing,
Lou ShaoJie,
Zhou QinHua,
Zhu LianWen,
Zhu LongFeng,
Li Lei
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500189
Subject(s) - dimethylacetamide , chemistry , catalysis , yield (engineering) , organic chemistry , alkyl , ketone , aryl , medicinal chemistry , materials science , solvent , metallurgy
In this study, we developed a general iron‐catalyzed α‐methylenation of ketones by using N,N ‐dimethylacetamide as the one‐carbon source. Various ketones, including aryl and alkyl ketones, enones, and dicarbonyl compounds were well tolerated to yield the corresponding α,β‐unsaturated carbonyl compounds in the presence of an iron catalyst, peroxides, and N,N ‐dimethylacetamide under aerobic conditions.