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Synthesis of Diazirine‐Based Photoreactive Saccharin Derivatives for the Photoaffinity Labeling of Gustatory Receptors
Author(s) -
Wang Lei,
Yoshida Takuma,
Muto Yasuyuki,
Murai Yuta,
Tachrim Zetryana Puteri,
Ishida Akiko,
Nakagawa Shiori,
Sakihama Yasuko,
Hashidoko Yasuyuki,
Masuda Katsuyoshi,
Hatanaka Yasumaru,
Hashimoto Makoto
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500184
Subject(s) - diazirine , chemistry , photoaffinity labeling , saccharin , moiety , trifluoromethyl , receptor , bitter taste , taste , stereochemistry , biochemistry , organic chemistry , medicine , alkyl , endocrinology
Saccharin is one of the most common artificial sweeteners that has a bitter taste at high concentrations. Currently, there are no detailed functional analyses of these gustatory receptors. Therefore, we designed and synthesized photoreactive saccharin derivatives that contain a (trifluoromethyl)diazirinyl moiety at the 5‐ or 6‐position for use as functional analysis tools for photoaffinity labeling.