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Synthesis of Rigid Analogues of Flavone by Intramolecular Heck Reaction
Author(s) -
Hou Chuanwei,
Chen Hao,
Xu Xing,
Zhu Fangxia,
Guo Lei,
Jiang Min,
Yang Chunhao,
Deng Lianfu
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500180
Subject(s) - chemistry , intramolecular force , heck reaction , yield (engineering) , scope (computer science) , substrate (aquarium) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , palladium , materials science , oceanography , computer science , metallurgy , programming language , geology
A novel concise method to synthesize rigid analogues of flavone by an intramolecular Heck reaction with wide substrate scope was developed. The key intermediates 3‐(2‐bromobenzyl)‐4 H ‐chromen‐4‐ones were prepared easily in two steps. Most compounds were obtained with moderate to good yields (34–90 % yield, 19 examples).