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Diastereoselective Synthesis of Indolindiones by Formal [5+1] Double Michael Cycloaddition to 4‐Cinnamoylpyrrolediones
Author(s) -
Silaichev Pavel S.,
Filimonov Valeriy O.,
Slepukhin Pavel A.,
Rubin Michael,
Maslivets Andrey N.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500141
Subject(s) - stereocenter , cycloaddition , michael reaction , chemistry , indoline , stereochemistry , organic chemistry , enantioselective synthesis , catalysis
An efficient [5+1] double Michael cycloaddition of enolates to 4‐cinnamoylpyrrole‐2,3‐diones was investigated; the reaction allows for the highly diastereoselective assembly of indoline scaffolds with up to three contiguous stereogenic centers.