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Synthesis of Chiral β‐Aminomalonates from 2‐Chlorotetrafluoroethanesulfinyl Aldimines through the Mannich Reaction
Author(s) -
Yang Kai,
Jiang Min,
Liu JinTao
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500134
Subject(s) - aldimine , chemistry , mannich reaction , organic chemistry , reaction conditions , transformation (genetics) , combinatorial chemistry , catalysis , biochemistry , gene
An efficient method for the synthesis of chiral β‐aminomalonates in good yields and with high diastereoselectivities was achieved through Mannich reactions between 2‐chlorotetrafluoroethanesulfinyl aldimines and dialkyl malonates in the presence of N ‐trimethylsilylimidazole. Further transformation of the products gave the corresponding β‐lactams in good yields and with high optical purities.