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Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius
Author(s) -
Smyrniotopoulos Vangelis,
Kiss Robert,
Mathieu Véronique,
Vagias Constantinos,
Roussis Vassilios
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500133
Subject(s) - chemistry , stereochemistry , in vitro , spectral analysis , cancer cell lines , biochemistry , cancer cell , cancer , biology , genetics , physics , quantum mechanics , spectroscopy
Three previously unknown diterpenes – spirosphaerol ( 1 ), anthrasphaerol ( 2 ) and corfusphaeroxide ( 3 ) – have been isolated from the red alga Sphaerococcus coronopifolius . Their structures were elucidated by spectral analysis, including NMR and MS. The isolated metabolites were evaluated for their in vitro antitumour activities against one murine and five human cancer cell lines.