A General Synthesis of Bis( o ‐azaheteroaryl)methane Derivatives from  N ‐Oxides of Azines and Azoles | Zendy

Szpunar Magdalena | Zendy; Loska Rafał | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A General Synthesis of Bis( o ‐azaheteroaryl)methane Derivatives from N ‐Oxides of Azines and Azoles

Author(s) -

Szpunar Magdalena,

Loska Rafał

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500072

Subject(s) - chemistry , isoquinoline , quinoline , cycloaddition , substituent , imidazole , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis

A general method of preparation of derivatives of bis( o ‐azaheteroaryl)methanes from aromatic N ‐oxides is reported, the key step of which is a 1,3‐dipolar cycloaddition between N ‐oxides of azines or azoles and in situ generated terminal difluoroalkenes containing an o ‐azaheteroaryl substituent at the double bond. Selected products were applied for the preparation of two novel unsymmetrical analogues of BODIPY fluorescent dyes, containing both an imidazole and a quinoline or isoquinoline unit.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research