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Mechanochemical Ritter Reaction: A Rapid Approach to Functionalized Amides at Room Temperature
Author(s) -
Dokli Irena,
Gredičak Matija
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500051
Subject(s) - ritter reaction , chemistry , tertiary alcohols , catalysis , solvent , substrate (aquarium) , organic chemistry , oceanography , geology
A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent‐free or low‐solvent environment by using a Brønsted acid catalyst. Its general application has been verified through a substrate screening comprising a wide range of functionalized nitriles as well as secondary and tertiary alcohols.