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The Suzuki–Miyaura Reaction Performed Using a Palladium–N‐Heterocyclic Carbene Catalyst and a Weak Inorganic Base
Author(s) -
Izquierdo Frédéric,
Corpet Martin,
Nolan Steven P.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500043
Subject(s) - chemistry , catalysis , carbene , aryl , palladium , base (topology) , organic chemistry , suzuki reaction , solvent , combinatorial chemistry , coupling reaction , boronic acid , polymer chemistry , alkyl , mathematics , mathematical analysis
N‐Heterocyclic carbenes (NHCs) have been shown to be useful ligands for the Suzuki–Miyaura cross‐coupling at low catalyst loadings. We now report that the commercially available and air‐stable [Pd(IPr)(cin)Cl] pre‐catalyst permits the formation of various functionalized biaryls from aryl chlorides and boronic acids (37 examples) under very mild conditions using a mixture of ethanol/water as solvent and an inorganic base.