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Synthesis of a Panel of Carbon‐13‐Labelled (Glyco)Sphingolipids
Author(s) -
Wisse Patrick,
Gold Henrik,
Mirzaian Mina,
Ferraz Maria J.,
Lutteke Ginger,
van den Berg Richard J. B. H. N.,
van den Elst Hans,
Lugtenburg Johan,
van der Marel Gijsbert A.,
Aerts Johannes M. F. G.,
Codée Jeroen D. C.,
Overkleeft Herman S.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500025
Subject(s) - sphingolipid , sphingosine , chemistry , moiety , lipidomics , amine gas treating , ceramide , biochemistry , stereochemistry , sphingosine 1 phosphate , organic chemistry , apoptosis , receptor
The synthesis of a focussed library of sphingolipids differing in the number and position of 13 C labels is described. The synthesised sphingolipids differ in substitution at both the sphingosine amine (either palmitoylated or unmodified) and the sphingosine primary hydroxyl (unmodified or glycosylated). Moreover, 13 C atoms are incorporated into either the sphingosine or the palmitate moiety, or both. This set of compounds is intended for use in relative quantitative lipidomics studies to gain insight into sphingolipid metabolism in healthy and diseased (lysosomal storage disorders) patients and animal models.