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Palladium‐Catalyzed C–H Bond Acylation of Acetanilides with Benzylic Alcohols under Aqueous Conditions
Author(s) -
Luo Feihua,
Yang Jun,
Li Zhengkai,
Xiang Haifeng,
Zhou Xiangge
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500016
Subject(s) - chemistry , acetanilide , palladium , catalysis , bimetallic strip , acylation , aqueous solution , benzophenone , organic chemistry , medicinal chemistry
Palladium‐catalyzed dehydrogenative coupling reactions between acetanilides and benzylic alcohols under aqueous conditions are reported. A wide range of benzophenone derivatives could be obtained in good to excellent yields up to 98 %. Mechanism studies showed that a bimetallic palladium cyclopalladated complex might be involved in the catalysis.
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