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Palladium‐Catalyzed α‐Arylation Reactions in Total Synthesis (Eur. J. Org. Chem. 1/2015)
Author(s) -
Sivanandan Sudheesh T.,
Shaji Ashna,
Ibnusaud Ibrahim,
Seechurn Carin C. C. Johansson,
Colacot Thomas J.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490106
Subject(s) - chemistry , palladium , catalysis , total synthesis , combinatorial chemistry , coupling reaction , organic synthesis , keto–enol tautomerism , surface modification , organic chemistry
The cover picture shows the scope of the α‐arylation reaction of carbonyl compounds, such as ketones, aldehydes, esters and amides in the total syntheses of natural products and active pharmaceutical ingredients (API). This is exciting, because α‐arylation reactions have emerged recently as one of the new trends in cross‐coupling reactions, in which the CH at the α position of the carbonyl group undergoes functionalization by enolization in the presence of a base, followed by a C–C coupling under the influence of a metal catalyst, typically Pd. The potential of this powerful methodology will be enormous for key steps in organic synthesis for small and large molecules. Details are presented in the Microreview by T. J. Colacot et al. on 38 ff .