Efficient Synthesis of 1,4,7‐Triazacyclononane and 1,4,7‐Triazacyclononane‐Based Bifunctional Chelators for Bioconjugation (Eur. J. Org. Chem. 35/2014)

The cover picture shows a family of chelators designed for metal‐based nuclear imaging and radiotherapy. A straightforward synthetic methodology enabled the preparation of TACN and a new generation of C ‐functionalized TACN derivatives for labeling biological vectors, such as antibodies or peptides. Thus, some bifunctional chelating agents were prepared such as the “ready‐to‐be‐grafted” p ‐NCS‐MA‐NOTA starting from the MA‐TACN precursor. Details are discussed in the article by F. Denat et al. on 7831 ff .