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Efficient Synthesis of 1,4,7‐Triazacyclononane and 1,4,7‐Triazacyclononane‐Based Bifunctional Chelators for Bioconjugation (Eur. J. Org. Chem. 35/2014)
Author(s) -
Désogère Pauline,
Rousselin Yoann,
Poty Sophie,
Bernhard Claire,
Goze Christine,
Boschetti Frédéric,
Denat Franck
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490099
Subject(s) - bioconjugation , bifunctional , chemistry , chelation , combinatorial chemistry , organic chemistry , catalysis
The cover picture shows a family of chelators designed for metal‐based nuclear imaging and radiotherapy. A straightforward synthetic methodology enabled the preparation of TACN and a new generation of C ‐functionalized TACN derivatives for labeling biological vectors, such as antibodies or peptides. Thus, some bifunctional chelating agents were prepared such as the “ready‐to‐be‐grafted” p ‐NCS‐MA‐NOTA starting from the MA‐TACN precursor. Details are discussed in the article by F. Denat et al. on 7831 ff .