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Selective Synthesis of Tetrasubstituted 4‐(Tetrazol‐5‐yl)‐1 H ‐imidazoles from 2‐(Tetrazol‐5‐yl)‐2 H ‐azirines (Eur. J. Org. Chem. 24/2014)
Author(s) -
Cardoso Ana Lúcia,
Lemos Américo,
Pinho e Melo Teresa M. V. D.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490066
Subject(s) - chemistry , imidazole , combinatorial chemistry , tetrazole , medicinal chemistry , stereochemistry
The cover picture shows the selective synthesis of new 4‐(tetrazol‐5‐yl)‐1 H ‐imidazoles by Zn(OTf) 2 ‐catalyzed reaction of 2‐(tetrazol‐5‐yl)‐2 H ‐azirines with imines. The synthetic methodology enabled the synthesis of a wide range of multi‐substituted 4‐(tetrazol‐5‐yl)‐1H‐imidazoles, which can be regarded as isosteres of 1 H ‐imidazole‐4‐carboxylic acid derivatives, a class of compounds with interesting biological properties, namely anti‐tuberculosis activity. Details are discussed in the article by T. M. V. D. Pinho e Melo et al. on p. p. 5159 ff . The authors thank Paulo Sanches for his contribution in designing the cover picture.