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Disulfide Formation Strategies in Peptide Synthesis (Eur. J. Org. Chem. 17/2014)
Author(s) -
Postma Tobias M.,
Albericio Fernando
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490045
Subject(s) - chemistry , disulfide bond , peptide , combinatorial chemistry , cyclic peptide , biochemistry
The cover picture shows that friendly and selective formation of disulfide bridges plays an important role in both peptides and proteins. They cause conformational constraints and increase the stability of such molecules making them more drug‐like. In nature, disulfide bonds are very common in animal and plant peptide toxins. Robust and convenient methods for the preparation of disulfide‐rich peptides are therefore beneficial for the drug‐discovery process. Details are presented in the Microreview by T. M. Postma and F. Albericio on p. 3519 ff.