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Total Synthesis of Quebrachamine through Macrolactamization (Eur. J. Org. Chem. 15/2014)
Author(s) -
Hsu ShihWen,
Cheng HsiuYi,
Huang AnChi,
Ho TseLok,
Hou DuenRen
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490039
Subject(s) - chemistry , cover (algebra) , total synthesis , yield (engineering) , stereochemistry , thermodynamics , physics , mechanical engineering , engineering
The cover picture shows the spectacular scenery of the Guoxing Interchange, located in Nantou, Taiwan. The loop‐like structure, lifted by the high piers up to 70 meters above the ground, equivalent to 23 stories, is the most high‐rise interchange system of the freeways in Taiwan. In the microscopic world, the nine‐membered, macrocycle of quebrachamine was constructed by direct lactamization. The conformationally restricted cis ‐2‐alkenylindole is the key component for the total synthesis, which was achieved in ten linear steps with a 9 % total yield. Details are discussed in the article by D.‐R. Hou et al. on p. 3109 ff. Photography by Aaron Fan.