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Nucleoside Analogues: Synthesis and Biological Properties of Azanucleoside Derivatives (Eur. J. Org. Chem. 11/2014)
Author(s) -
Hernández Dácil,
Boto Alicia
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490027
Subject(s) - chemistry , nucleoside , combinatorial chemistry , biochemical engineering , computational biology , nanotechnology , stereochemistry , materials science , engineering , biology
The cover picture shows a two‐meter, wind‐beaten tajinaste plant in Tenerife (Canary Islands), which represents the many turns involved in the process of developing drugs or materials inspired by nature. Thus, natural nucleosides (at the bottom of the tajinaste plant and the real process) have inspired a diversity of nucleoside analogues with improved stability or pharmacological properties, such as the azanucleosides (first bend of the plant/process). After different refining cycles, these azanucleosides have proven to be promising drug candidates (from potent antitumorals to selective antimalarials or antimicrobials) or valuable components of oligonucleotides with improved stability, binding, or hybrydization properties. Since the potential of azanucleosides is still emerging, a variety of other activities will likely appear in the future, as represented by the end of the tajinaste pointing to the sky. Details are presented in the Microreview by D. Hernndez and A. Boto on p. 2201 ff. .