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Metal–Organocatalytic Tandem Azide Addition/Oxyamination of Aldehydes for the Enantioselective Synthesis of β‐Amino α‐Hydroxy Esters (Eur. J. Org. Chem. 9/2014)
Author(s) -
Shyam Pranab K.,
Jang HyeYoung
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490021
Subject(s) - chemistry , enantioselective synthesis , cinnamaldehyde , azide , tandem , catalysis , organocatalysis , organic chemistry , amine gas treating , optically active , combinatorial chemistry , materials science , composite material
The cover picture shows an easy and efficient transformation of cinnamaldehyde and its derivatives to optically active β‐azido α‐oxyaminated aldehydes by the cooperation of an organocatalyst (chiral sec‐amine) and an iron catalyst. Furthermore, synthesized β‐azido α‐oxyaminated aldehydes were easily modified to afford pharmaceutically valuable β‐amino α‐hydroxy esters in three steps without loss of enantio‐ and diastereoselectivity. Details are discussed in the Short Communication by P. K. Shyam and H.‐Y. Jang on p. 1817 ff.