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A Convenient Method for the Asymmetric Synthesis of Fluorinated α‐Amino Acids from Alcohols (Eur. J. Org. Chem. 6/2014)
Author(s) -
Drouet Fleur,
Noisier Anaïs F. M.,
Harris Craig S.,
Furkert Daniel P.,
Brimble Margaret A.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490012
Subject(s) - chemistry , reagent , combinatorial chemistry , amino acid , electrophile , mitsunobu reaction , alcohol , organic chemistry , catalysis , biochemistry
The cover picture shows a novel and high‐throughput process to prepare rare polyfluorinated α‐amino acids in high chemical and optical yields directly from stable alcohol pro‐electrophiles using the Mitsunobu–Tsunoda reagent. This simple library‐style process, providing rapid access to this rare class of amino acids for biological and material‐science applications, was discovered in AstraZeneca's Reims Laboratories (inset photo) and optimized in the peptide laboratories (main photo) at Auckland University, New Zealand. Details are discussed in the article by M. A. Brimble et al. on p. 1195 ff.