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The Synthetic Challenge of Thioglycolurils (Eur. J. Org. Chem. 5/2014)
Author(s) -
Singh Mandeep,
Parvari Galit,
Botoshansky Mark,
Keinan Ehud,
Reany Ofer
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201490009
Subject(s) - chemistry , paraformaldehyde , combinatorial chemistry , cover (algebra) , nanotechnology , calixarene , organic chemistry , molecule , mechanical engineering , materials science , engineering
The cover picture shows a metaphorical representation of thiocucurbituril as a Holy Grail of host?guest chemistry. As detailed in the article by E. Keinan, O. Reany et al. on p. 933 ff. , several thioglycoluril derivatives that could serve as potential precursors on the way to this highly desirable target were synthesized and fully characterized. In contrast to the known chemistry of glycoluril, dithioglycoluril could not be used for the synthesis of thiocucurbituril due to its limited stability in acidic media. Attempts to co‐oligomerize various thioglycoluril derivatives with paraformaldehyde suggest that alternative synthetic approaches towards thiocucurbituril should be pursued. Ms. Dina Mid of the Technion Printing Unit designed the cover picture.