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Remote Amide‐Controlled Gold‐Catalyzed Stereoselective Hydro‐heteroarylation of Acrylamides: Access to Pyrido[3,4‐ b ]indoles
Author(s) -
Butani Himanshu H.,
Vachhani Dipak D.,
Bhoya Umed C.,
Shah Anamik K.,
Van der Eycken Erik V.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403682
Subject(s) - amide , chemistry , stereoselectivity , catalysis , combinatorial chemistry , silver salts , organic chemistry
The amide functionality was used as a remote control for the stereoselective hydro‐heteroarylation of acrylamides. This gold‐catalyzed carbocyclization provides a diversity‐oriented and concise route to biologically important pyrido[3,4‐ b ]indoles. Moreover, the adverse effect of silver salts on this hydro‐heteroarylation was also studied.