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Palladium‐Catalyzed Oxidative Aminocarbonylation by Decarboxylative Coupling: Synthesis of Alkynyl Amides
Author(s) -
Hwang Jinil,
Choi Jinseop,
Park Kyungho,
Kim Wonyoung,
Song Kwang Ho,
Lee Sunwoo
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403644
Subject(s) - chemistry , palladium , nitrile , ketone , catalysis , acetonitrile , functional group , carbon monoxide , organic chemistry , medicinal chemistry , oxidative coupling of methane , combinatorial chemistry , polymer
Alkynyl amides were synthesized from a palladium‐catalyzed coupling reaction of alkynyl carboxylic acids and amines under carbon monoxide. The reaction was conducted with palladium(II) acetate (5 mol‐%) and silver(I) oxide (1.0 equiv.) in acetonitrile at 80 °C for 1 h. This method provides good to moderate product yields and good functional group tolerance towards ketone, ester, and nitrile groups.