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Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
Author(s) -
Vasiloiu Maria,
Gaertner Peter,
Zirbs Ronald,
Bica Katharina
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403555
Subject(s) - chemistry , ionic liquid , transfer hydrogenation , chirality (physics) , enantioselective synthesis , ruthenium , aqueous solution , organic chemistry , catalysis , combinatorial chemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Hydrophilic coordinating chiral ionic liquids with an amino alcohol substructure were developed and efficiently applied to the asymmetric reduction of ketones. Their careful design and adaptability to the desired reaction conditions allow for these chiral ionic liquids to be used as the sole source of chirality in a ruthenium‐catalyzed transfer hydrogenation reaction of aromatic ketones. When used in this reaction system, these chiral ionic liquids afforded excellent yields and high enantioselectivities.