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Synthesis of 2‐Acylphenol and Flavene Derivatives from the Ruthenium‐Catalyzed Oxidative C–H Acylation of Phenols with Aldehydes
Author(s) -
Lee Hanbin,
Yi Chae S.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403518
Subject(s) - chemistry , phenols , ruthenium , acylation , catalysis , oxidative coupling of methane , aldehyde , phenol , hydride , organic chemistry , oxidative phosphorylation , medicinal chemistry , metal , biochemistry
The cationic ruthenium hydride complex [(C 6 H 6 )(PCy 3 )(CO)RuH] + BF 4 – has been found to be an effective catalyst for the oxidative C–H coupling reaction of phenols with aldehydes to give 2‐acylphenol compounds. The coupling of phenols with α,β‐unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C–H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts.