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Diastereoselective Synthesis of 2,6‐Diaryltetrahydrothiopyran‐4‐ones by Phase‐Transfer Catalysis
Author(s) -
Gendron Thibault,
Kessedjian Hripsimée,
DavioudCharvet Elisabeth,
Lanfranchi Don Antoine
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403516
Subject(s) - chemistry , diastereomer , catalysis , combinatorial chemistry , scope (computer science) , phase (matter) , stereochemistry , organic chemistry , computer science , programming language
Two efficient phase‐transfer‐catalyzed protocols for the diastereoselective synthesis of cis and trans isomers of 2,6‐diaryltetrahydrothiopyran‐4‐ones (2,6‐DATHTPs) have been developed. In a study of the scope of the reactions, differently substituted 2,6‐DATHTPs were successfully accessed in high yields and diastereomeric excessses on both experimental and preparative scales.