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Copper‐Catalyzed Asymmetric Oxidative Cross‐Coupling of 2‐Naphthols with Aryl Methyl Ketones
Author(s) -
Deng Tao,
Wang Hongjun,
Cai Chun
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403512
Subject(s) - chemistry , aryl , catalysis , oxidative coupling of methane , oxidative phosphorylation , furan , molecular oxygen , copper , medicinal chemistry , organic chemistry , combinatorial chemistry , biochemistry , alkyl
A copper‐catalyzed asymmetric oxidative cross‐coupling reaction of 2‐naphthols with aryl methyl ketones has been developed. This transformation provides an efficient route to various functionalized naphtho[2,1‐ b ]furan‐1(2 H )‐ones in an enantiomerically enriched manner with molecular oxygen in air as the oxidant (52–89 % yields, up to 87 % ee ). The reaction leads to the formation of a new quaternary carbon center within 3(2 H )‐furanones.
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