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Benzoyl Peroxide Promoted Radical ortho ‐Alkylation of Nitrogen Heteroaromatics with Simple Alkanes and Alcohols
Author(s) -
Fang Lei,
Chen Liangshun,
Yu Jianjun,
Wang Limin
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403479
Subject(s) - chemistry , regioselectivity , benzoyl peroxide , alkylation , catalysis , peroxide , organic chemistry , nitrogen , medicinal chemistry , polymerization , polymer
A catalytic amount of benzoyl peroxide (BPO)‐initiated cross‐dehydrogenative coupling reaction of N ‐iminopyridine ylides with simple alkanes and alcohols leads to the corresponding 2‐alkylpyridines with high regioselectivity in moderate to good yields without an additional reduction step to remove the activated group.
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