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Synthesis of Pyridylphosphonates by Rhodium‐Catalyzed [2+2+2] Cycloaddition of 1,6‐ and 1,7‐Diynes with Diethyl Phosphorocyanidate
Author(s) -
Kashima Kenichi,
Ishii Masahiro,
Tanaka Ken
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403452
Subject(s) - chemistry , rhodium , cycloaddition , cationic polymerization , catalysis , bicyclic molecule , medicinal chemistry , binap , organic chemistry , enantioselective synthesis
The convenient and atom‐economical synthesis of substituted bicyclic pyridylphosphonates has been achieved by the cationic rhodium(I)/H 8 ‐binap‐complex‐catalyzed [2+2+2] cycloaddition of 1,6‐ and 1,7‐diynes with diethyl phosphorocyanidate. These reactions may proceed via an azarhodacyclopentadiene intermediate in addition to the rhodacyclopentadiene intermediate.