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A Tuned Bicyclic Proazaphosphatrane for Catalytically Enhanced N ‐Arylation Reactions with Aryl Chlorides
Author(s) -
Kim So Han,
Kim Min,
Verkade John G.,
Kim Youngjo
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403428
Subject(s) - chemistry , bicyclic molecule , aryl , ligand (biochemistry) , catalysis , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , alkyl , receptor
The N ‐arylation of various amines with aryl chlorides proceeded in good‐to‐excellent yields in the presence of P[N{( p ‐NMe 2 )C 6 H 4 CH 2 }CH 2 CH 2 ] 3 N ( 1e , a new electron‐rich proazaphosphatrane ligand) and small amounts of Pd 2 (dba) 3 (dba = dibenzylideneacetone). This catalytic system was also very effective for the synthesis of carbazoles.