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Ruthenium‐Catalyzed Conjugate Hydrogenation of α,β‐Enones by in situ Generated Dihydrogen from Paraformaldehyde and Water
Author(s) -
Li Wanfang,
Wu XiaoFeng
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403359
Subject(s) - chemistry , paraformaldehyde , ruthenium , bifunctional , conjugate , catalysis , allylic rearrangement , noyori asymmetric hydrogenation , selectivity , in situ , combinatorial chemistry , organic chemistry , medicinal chemistry , mathematical analysis , mathematics
Notwithstanding that the highly selective hydrogenation of α,β‐enones to allylic alcohols can be realized by using Noyori's Ru bifunctional system, the selective reduction of the C=C bonds in α,β‐enones without touching the C=O bonds still lacks a general, simple, and efficient procedure. Ruthenium‐catalyzed conjugate hydrogenation of various α,β‐enones to saturated ketones with high selectivity was investigated. The most important feature of this procedure was that hydrogen in situ generated from paraformaldehyde (or formalin) and water was employed as the reductant.