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Catalytic Asymmetric Alkylation of Aryl Heteroaryl Ketones
Author(s) -
Ortiz Pablo,
del Hoyo Ana M.,
Harutyunyan Syuzanna R.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403297
Subject(s) - chemistry , alkylation , aryl , catalysis , reagent , reactivity (psychology) , combinatorial chemistry , enantioselective synthesis , organic chemistry , alkyl , alternative medicine , pathology , medicine
Tertiary diarylmethanols are highly bioactive structural motifs. A new strategy to access chiral tertiary diarylmethanols through copper‐catalyzed direct alkylation of (di)(hetero)aryl ketones by using Grignard reagents was developed. The low reactivity and the similarity of the enantiotopic faces of bis‐aromatic ketones were partially overcome, which resulted in moderate to good yields and enantioselectivities.