Premium
Synthesis of Tetrasubstituted Symmetrical Pyrazines from β‐Keto γ‐Amino Esters: A Mild Strategy for Self‐Dimerization of Peptides
Author(s) -
Ganesh Kumar Mothukuri,
Thombare Varsha J.,
Bhaisare Rupal D.,
Adak Anindita,
Gopi Hosahudya N.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403237
Subject(s) - chemistry , amino acid , combinatorial chemistry , side chain , organic chemistry , scope (computer science) , peptide , stereochemistry , biochemistry , polymer , computer science , programming language
A facile synthesis of highly symmetrical tetrasubstituted pyrazines through simple aerial oxidation of β‐keto γ‐amino esters is reported. The scope of the reaction was examined by use of various amino acid side‐chain functional groups and peptides. The mild and efficient transformation of β‐keto γ‐amino esters into pyrazines may serve as an attractive strategy for self‐dimerization of peptides.