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Synthesis of ( E )‐1,4‐Enediones from α‐Halo Ketones Through a Sodium Sulfinate Mediated Reaction
Author(s) -
Li SuYi,
Wang XiaoBing,
Jiang Neng,
Kong LingYi
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403236
Subject(s) - chemistry , halo , sodium , selectivity , reaction conditions , combinatorial chemistry , organic chemistry , catalysis , physics , quantum mechanics , galaxy
We developed a mild and practical protocol for the synthesis of 1,4‐enedione from α‐halo ketones through a sodium sulfinate mediated reaction. This reaction enables the construction of symmetric and unsymmetric 1,4‐enedione with complete E selectivity. Sodium 4‐toluenesulfinate plays an important role in this reaction.