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Nickel‐Catalyzed Decarboxylative Arylation of Heteroarenes through sp 2 C–H Functionalization
Author(s) -
Yang Ke,
Wang Peng,
Zhang Cheng,
Kadi Adnan A.,
Fun HoongKun,
Zhang Yan,
Lu Hongjian
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403234
Subject(s) - chemistry , catalysis , nickel , surface modification , decarboxylation , aryl , combinatorial chemistry , organic chemistry , alkyl
The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel‐catalyzed sp 2 C–H functionalization process was developed. This process provides the first examples of decarboxylative cross‐coupling reactions with aromatic acids through nickel catalysis and tolerates a variety of functional groups. Moreover, this method provides efficient access to 2‐aryl‐substituted azoles, an important structural unit in natural products, medicinal compounds, and functional materials.