An Improved Protocol for the Synthesis of α‐Trifluoromethylthio‐Substituted Ketones by Copper‐Mediated Trifluoromethylthiolation of α‐Bromo Ketones

An efficient and practical approach to α‐trifluoromethylthio‐substituted ketones was developed. The trifluoromethylthiolation of (bpy)Cu(SCF 3 ) (bpy = 2,2′‐bipyridyl) with various α‐bromo ketones afforded the desired α‐trifluoromethylthio‐substituted ketones in good yields. The reaction tolerates more functionally than previously reported methods and demonstrates efficient scalability and practicality.