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An Improved Protocol for the Synthesis of α‐Trifluoromethylthio‐Substituted Ketones by Copper‐Mediated Trifluoromethylthiolation of α‐Bromo Ketones
Author(s) -
Huang Yangjie,
He Xing,
Li Haohong,
Weng Zhiqiang
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403221
Subject(s) - chemistry , copper , combinatorial chemistry , ketone , organic chemistry
Abstract An efficient and practical approach to α‐trifluoromethylthio‐substituted ketones was developed. The trifluoromethylthiolation of (bpy)Cu(SCF 3 ) (bpy = 2,2′‐bipyridyl) with various α‐bromo ketones afforded the desired α‐trifluoromethylthio‐substituted ketones in good yields. The reaction tolerates more functionally than previously reported methods and demonstrates efficient scalability and practicality.