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Functionalization of the Benzylic C–H Bonds in Azaarenes by Cobalt‐Catalyzed 1,4‐Addition to Enones
Author(s) -
Jamal Zaini,
Teo YongChua,
Wong LingKeong
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403203
Subject(s) - chemistry , surface modification , catalysis , electrophile , lewis acids and bases , cobalt , medicinal chemistry , organic chemistry , combinatorial chemistry , lewis acid catalysis , polymer chemistry
Functionalization of the C(sp 3 )–H bonds in azaarenes was catalyzed by CoCl 2 as an inexpensive Lewis acid catalyst. Enones were demonstrated to be good C=C electrophilic acceptors for the construction of various azaarene‐containing 1,4‐addition products in yields of up to 95 %.