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Design and Synthesis of 3‐Trifluoromethyl‐3 H ‐pyrazoles and Further Investigations of Their Transformation to 1 H ‐Pyrazoles
Author(s) -
Sha Qiang,
Liu Haixuan,
Wei Yunyang
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403141
Subject(s) - chemistry , regioselectivity , trifluoromethyl , cycloaddition , intramolecular force , sigmatropic reaction , transformation (genetics) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis , alkyl , gene , biochemistry
An efficient intramolecular cycloaddition strategy for the synthesis of trifluoromethyl‐substituted 3 H ‐pyrazoles was developed. Subsequently, their wide applications were demonstrated: they (1) react with dioxane by a radical process and (2) undergo [1,5] sigmatropic rearrangements. These applications are useful as the products were obtained in high yields and with excellent regioselectivity.