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Direct Arylation of Benzo[ b ]furan and Other Benzo‐Fused Heterocycles
Author(s) -
DaoHuy Toan,
Haider Maximilian,
Glatz Fabian,
Schnürch Michael,
Mihovilovic Marko D.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403125
Subject(s) - chemistry , furan , thiophene , regioselectivity , indole test , reagent , aryl , stereochemistry , catalysis , combinatorial chemistry , organic chemistry , alkyl
The direct arylation of benzo[ b ]furan, benzo[ b ]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2‐position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo‐fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[ b ]furan.