Direct Arylation of Benzo[ b ]furan and Other Benzo‐Fused Heterocycles | Zendy

DaoHuy Toan | Zendy; Haider Maximilian | Zendy; Glatz Fabian | Zendy; Schnürch Michael | Zendy; Mihovilovic Marko D. | Zendy

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Direct Arylation of Benzo[ b ]furan and Other Benzo‐Fused Heterocycles

Author(s) -

DaoHuy Toan,

Haider Maximilian,

Glatz Fabian,

Schnürch Michael,

Mihovilovic Marko D.

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201403125

Subject(s) - chemistry , furan , thiophene , regioselectivity , indole test , reagent , aryl , stereochemistry , catalysis , combinatorial chemistry , organic chemistry , alkyl

The direct arylation of benzo[ b ]furan, benzo[ b ]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2‐position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo‐fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[ b ]furan.

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