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First Microwave‐Assisted Catalytic Wittig Reaction
Author(s) -
Werner Thomas,
Hoffmann Marcel,
Deshmukh Sunetra
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403113
Subject(s) - wittig reaction , catalysis , chemistry , microwave irradiation , microwave , reaction conditions , organic chemistry , combinatorial chemistry , oxide , photochemistry , physics , quantum mechanics
Abstract We introduce a novel catalytic Wittig reaction based on an inexpensive and readily available phosphane oxide as a precatalyst. The performance of the reaction under microwave irradiation led to significantly improved yields and reaction rates relative to those obtained under conventional heating. Moreover, herein we enclose the first example of the asymmetric catalytic Wittig reaction based on a chiral phosphane as the catalyst.