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Decarboxylation of a Wide Range of Amino Acids with Electrogenerated Hypobromite
Author(s) -
Matthessen Roman,
Claes Laurens,
Fransaer Jan,
Binnemans Koen,
De Vos Dirk E.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403112
Subject(s) - decarboxylation , chemistry , bromide , electrochemistry , electrolyte , redox , amino acid , combinatorial chemistry , organic chemistry , catalysis , electrode , biochemistry
Bromide‐assisted electrochemical decarboxylation efficiently produces valuable nitriles in high yields from a wide range of naturally occurring amino acids in a single step. Bromide salts are used as both redox mediators and supporting electrolytes in a simple one‐compartment setup. As demonstrated for lysine, the selectivity of the decarboxylation can be tuned towards nitriles, amines or amides.