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Buchwald–Hartwig Reactions of Monohaloflavones
Author(s) -
Kónya Krisztina,
Pajtás Dávid,
KissSzikszai Attila,
Patonay Tamás
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403108
Subject(s) - chemistry , amination , aniline , phosphine , combinatorial chemistry , amino acid , conjugate , reductive amination , primary (astronomy) , organic chemistry , stereochemistry , catalysis , biochemistry , mathematical analysis , physics , mathematics , astronomy
The article describes the amination of different monobromo‐ or monochloroflavones with primary and secondary alkylamines and aniline derivatives by Buchwald–Hartwig reaction. The influence of the phosphine ligands used is described. The use of amino acid derivatives as a nitrogen source is also demonstrated. This latter reaction allows the synthesis of unique flavone–amino‐acid conjugates.