Concise Synthesis of Vesnarinone and Its Analogues by Using Pd‐Catalyzed C–N Bond‐Forming Reactions | Zendy

See Yi Yang | Zendy; Dang Tuan Thanh | Zendy; Chen Anqi | Zendy; Seayad Abdul Majeed | Zendy

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Concise Synthesis of Vesnarinone and Its Analogues by Using Pd‐Catalyzed C–N Bond‐Forming Reactions

Author(s) -

See Yi Yang,

Dang Tuan Thanh,

Chen Anqi,

Seayad Abdul Majeed

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201403054

Subject(s) - chemistry , amination , yield (engineering) , catalysis , homogeneous , combinatorial chemistry , organic chemistry , metallurgy , materials science , physics , thermodynamics

An efficient and concise synthesis of vesnarinone and its analogues from readily available starting materials and by using catalytic C–N bond‐forming reactions is reported. In this protocol, a homogeneous Pd‐catalyzed Buchwald–Hartwig amination and a supported Pd nanoparticles catalyzed aminocarbonylation were utilized as the two key reactions to prepare vesnarinone in an overall yield of 73 %. Sixteen analogues were also synthesized in up to 89 % overall yield.

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