Premium
Modular Access to Highly Functionalised Tetrahydroquinolines
Author(s) -
Cordero Franca M.,
Khairnar Bhushan B.,
Brandi Alberto
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201403025
Subject(s) - chemistry , nitrone , cycloaddition , combinatorial chemistry , cleavage (geology) , modular design , stereochemistry , organic chemistry , catalysis , computer science , geotechnical engineering , fracture (geology) , engineering , operating system
Highly functionalised tetrahydroquinolines have been obtained by a modular approach consisting of a nitrone 1,3‐dipolar cycloaddition to 2‐bromostyrene followed by isoxazolidine N–O cleavage and copper‐catalysed aromatic N ‐substitution/cyclisation. A 1,2,3,4‐tetrahydro‐1,8‐naphthyridine was obtained in the same way.