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Ruthenium‐Catalyzed Switchable N–H/C–H Alkenylation of 6‐Phenyl(dihydro)pyridazinones with Alkynes
Author(s) -
Wang Wei,
Liang Lei,
Xu Fengrong,
Huang Wenjie,
Niu Yan,
Sun Qi,
Xu Ping
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402986
Subject(s) - chemistry , ruthenium , catalysis , pharmacophore , selectivity , combinatorial chemistry , oxygen , medicinal chemistry , organic chemistry , polymer chemistry , stereochemistry
A ruthenium‐catalyzed switchable N–H/C–H alkenylation reaction of 6‐phenyl‐(dihydro)pyridazin‐3(2 H )‐ones triggered by a nitrogen/oxygen atmosphere was developed. To achieve switchable modification of the two important sites of the widely used pharmacophore, a simple and efficient procedure containing two optimized ruthenium catalytic systems was utilized, which afforded excellent activity, high selectivity, and good tolerance of a wide range of functional groups.