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Ruthenium‐Catalyzed Alkenylation of Arenes with Alkynes or Alkenes by 1,2,3‐Triazole‐Directed C–H Activation
Author(s) -
Li Xing Guang,
Liu Kai,
Zou Gang,
Liu Pei Nian
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402938
Subject(s) - chemistry , ruthenium , regioselectivity , catalysis , medicinal chemistry , triazole , combinatorial chemistry , organic chemistry
The ruthenium‐catalyzed alkenylation of arenes with alkynes or alkenes has been achieved by using 1,2,3‐triazole as the directing group for the C–H activation. With [Ru( p ‐cymene)Cl 2 ] 2 as the catalyst and Cu(OAc) 2 · H 2 O and AgSbF 6 as additives, various triazole‐substituted arenes reacted readily with a range of internal alkynes or terminal alkenes to afford di‐ or monoalkenylated arenes with high regioselectivity and in moderate‐to‐excellent yields.