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Efficient Cross‐Coupling of Dioxazaborocanes with α‐Phosphate Enamides
Author(s) -
Gigant Nicolas,
Honraedt Aurélien,
Gras Emmanuel,
Gillaizeau Isabelle
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402927
Subject(s) - chemistry , phosphate , palladium , boron , coupling (piping) , combinatorial chemistry , coupling reaction , catalysis , organic chemistry , stereochemistry , mechanical engineering , engineering
A range of readily available α‐phosphate enamides were subjected to (hetero)aromatic dioxazaborocanes (DABO boronates), providing the desired α‐functionalized enamides in high yields via palladium‐catalyzed cross‐coupling reactions. Notably, the reaction proceeds in the presence of a slight excess of boron derivatives and tolerates cyclic, nonaromatic and/or electron‐rich enamides.