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Neocryptolepine (Cryprotackieine), A Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity
Author(s) -
Bracca Andrea B. J.,
Heredia Daniel A.,
Larghi Enrique L.,
Kaufman Teodoro S.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402910
Subject(s) - natural product , chemistry , isolation (microbiology) , total synthesis , product (mathematics) , natural (archaeology) , biochemical engineering , combinatorial chemistry , stereochemistry , bioinformatics , biology , engineering , paleontology , geometry , mathematics
The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid neocryptolepine are discussed. Aspects relating to the isolation of the natural product from Cryptolepis sanguinolenta , as well as its performance in various biological tests and spectroscopic studies involving the natural product, are also reviewed.