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Rhodium‐Catalyzed Oxidative Perfluoroalkenylation by Carbonyl Group Directed C–H Bond Activation
Author(s) -
Kathiravan Subban,
Nicholls Ian A.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402904
Subject(s) - chemistry , rhodium , catalysis , functional group , reagent , oxidative phosphorylation , carbonyl group , acrylate , combinatorial chemistry , organic chemistry , group (periodic table) , medicinal chemistry , biochemistry , monomer , polymer
The selective activation of C–H bonds under mild Rh III catalytic conditions has been developed for the perfluoroalkenylation of various cyclic and acyclic aromatic ketones. This protocol uses versatile reagents and mild conditions. It requires a very low catalyst loading and has exceptional functional group tolerance as well as provides products in good to excellent yields. An application of this approach was described for the preparation of perfluoroethyl acrylate derivatives of biologically active substances.